For the Commodity Futures Trading Commission (CFTC or Commission), 2018 was characterized by (1) an active enforcement program emphasizing cooperation and self-reporting, (2) increasing cross-border tension over supervision of central counterparties (CCPs), (3) publication of a far-reaching proposed rule to restructure the framework governing swap execution facilities (SEFs), (4) evolving Commission oversight of virtual currencies, and (5) publication by Chairman J. Christopher Giancarlo of his vision for market structure reform and cross-border harmonization. We discuss these five areas of Commission action in 2018 and what may be ahead in 2019.