This post summarizes the U.S. Food and Drug Administration (FDA) Compliance Program Guidance Manual (CPGM) for food facilities subject to preventive controls and sanitary human food operation requirements. As an overview, FDA’s “Compliance Programs” provide instructions to FDA personnel for conducting activities to evaluate industry compliance with the Federal Food, Drug, and Cosmetic Act (FFDCA) and other laws administered by FDA. This compliance program in particular covers inspections of businesses subject to the Preventive Controls for Human Foods (PCHF) rule that was issued under the FDA Food Safety Modernization Act (FSMA).